Inhibitory neurons in human cortical circuits: substrate for cognitive dysfunction in schizophrenia

Curr Opin Neurobiol. 2014 Jun;26:22-6. doi: 10.1016/j.conb.2013.11.003. Epub 2013 Nov 30.

Abstract

Schizophrenia is a disorder of cognitive neurodevelopment. At least some of the core cognitive deficits of the illness appear to be the product of impaired gamma frequency oscillations which depend, in part, on the inhibitory actions of a subpopulation of cortical GABA neurons that express the calcium binding protein parvalbumin (PV). Recent studies have revealed new facets of the development of PV neurons in primate neocortex and of the nature of their molecular alterations in individuals with schizophrenia. Other recent studies in model systems provide insight into how these alterations may arise in the course of cortical circuitry development.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Cerebral Cortex / pathology*
  • Cognition Disorders / etiology*
  • Cognition Disorders / pathology*
  • Humans
  • Nerve Net / pathology*
  • Neural Inhibition / physiology*
  • Parvalbumins / metabolism
  • Schizophrenia / complications*
  • gamma-Aminobutyric Acid / metabolism

Substances

  • Parvalbumins
  • gamma-Aminobutyric Acid