Abstract
An indirect immunofluorescence method was utilized to identify substance P-like immunoreactive (SPLI) and neurofilament protein immunoreactive (NFIR) fibers in the lumbar facet joint capsule and supraspinous ligament of the rabbit. The results demonstrated a large population of NFIR fibers, indicating that these tissues are richly innervated, and a smaller population of SPLI fibers. In some fibers, neurofilament protein and substance P were colocalized. The data suggest that the facet joint capsule and the supraspinous ligament contain SPLI nociceptive fibers that could be a source of low back pain.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Monoclonal
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Cytoskeleton / ultrastructure*
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Fluorescent Antibody Technique
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Intermediate Filament Proteins / analysis*
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Intermediate Filament Proteins / immunology
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Intermediate Filaments / ultrastructure*
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Joints / cytology*
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Ligaments / cytology
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Neurofilament Proteins
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Rabbits
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Spine / cytology
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Substance P / analysis*
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Substance P / immunology
Substances
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Antibodies, Monoclonal
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Intermediate Filament Proteins
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Neurofilament Proteins
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Substance P