Leukemia propagating cells Akt up

Cancer Cell. 2014 Mar 17;25(3):263-5. doi: 10.1016/j.ccr.2014.02.022.


Individual cancer cells can exhibit striking differences in tumorigenic potential following experimental transplantation, but the molecular pathways that regulate this activity remain poorly understood. In this issue of Cancer Cell, Blackburn and colleagues report that Akt signaling regulates both leukemia-propagating potential and proliferation rate via distinct pathways in T-ALL.

Publication types

  • Comment

MeSH terms

  • Animals
  • Clonal Evolution / genetics*
  • Humans
  • Mechanistic Target of Rapamycin Complex 1
  • Multiprotein Complexes / metabolism*
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / metabolism*
  • Proto-Oncogene Proteins c-akt / metabolism*
  • Proto-Oncogene Proteins c-myc / metabolism*
  • TOR Serine-Threonine Kinases / metabolism*


  • Multiprotein Complexes
  • Proto-Oncogene Proteins c-myc
  • TOR Serine-Threonine Kinases
  • Mechanistic Target of Rapamycin Complex 1
  • Proto-Oncogene Proteins c-akt