Cardiorespiratory events in extremely low birth weight infants: neurodevelopmental outcome at 1 and 2 years

J Perinatol. 2014 Jul;34(7):562-5. doi: 10.1038/jp.2014.44. Epub 2014 Mar 20.


Objective: To examine the association between cardiorespiratory events (CRE) and neurodevelopmental (ND) outcome at 8 and 20 months corrected age (CA) in a contemporary extremely low birth weight (ELBW )cohort.

Study design: Retrospective chart review of 98 ELBW infants born in 2009 to 2010 who completed ND assessments at 8 and 20 months CA. Neonatal, sociodemographic, CRE and ND data were collected. ND outcome measures included neurologic examination and results from the Bayley Scales of Infant and Toddler Development-III. Multiple regression analyses adjusted for the impact of neonatal risk factors on ND outcome.

Result: After adjusting for neonatal and social variables, greater frequency of CRE was related to worse language scores at 8 months, while CRE of greater severity were related to worse language at 20 months CA.

Conclusion: CRE in ELBW infants have impact on language development in the first two years of life.

MeSH terms

  • Apnea / complications
  • Apnea / epidemiology*
  • Bradycardia / complications
  • Bradycardia / epidemiology*
  • Child Development*
  • Cohort Studies
  • Developmental Disabilities / epidemiology*
  • Developmental Disabilities / etiology
  • Female
  • Humans
  • Infant
  • Infant, Extremely Low Birth Weight / growth & development*
  • Infant, Newborn
  • Language Development
  • Male
  • Neurologic Examination
  • Regression Analysis
  • Retrospective Studies
  • Risk Factors