A study on the effect of resveratrol on lipid metabolism in hyperlipidemic mice

Afr J Tradit Complement Altern Med. 2013 Nov 2;11(1):209-12. eCollection 2014.


Background: The content of resveratrol is relatively high in Polygonum cuspidatum Sieb. et Zucc., and the resveratrol has the effect of blood vessel dilating, microcirculation improving, platelet aggregation inhibiting and anti-cancer. The objective of this paper was to study the effect of resveratrol on lipid metabolism in hyperlipidemia mice.

Materials and methods: Through the establishment of an experimental mouse model of hyperlipidemia, the effect of resveratrol on change in total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDL-c) levels in mouse serum were determined.

Results: Resveratrol group can apparently reduce TC, TG, LDL-c and AI of hyperlipidemic mice in a dose effect manner.

Conclusion: We concluded that resveratrol can effectively reduce blood lipid levels of hyperlipidemic mice.

Keywords: HDL-c; LDL-c; Resveratrol; TC; TG; hyperlipidemia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arteriosclerosis / blood
  • Arteriosclerosis / prevention & control
  • Cholesterol / blood*
  • Dose-Response Relationship, Drug
  • Fallopia japonica / chemistry*
  • Hyperlipidemias / blood
  • Hyperlipidemias / drug therapy*
  • Lipid Metabolism / drug effects
  • Male
  • Mice
  • Phytotherapy*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*
  • Resveratrol
  • Stilbenes / pharmacology
  • Stilbenes / therapeutic use*
  • Triglycerides / blood*


  • Plant Extracts
  • Stilbenes
  • Triglycerides
  • Cholesterol
  • Resveratrol