Early predictive value of multifunctional skin-infiltrating lymphocytes in anticancer immunotherapy

Oncoimmunology. 2014 Jan 1;3(1):e27219. doi: 10.4161/onci.27219.


Bioassays that predict clinical outcome are essential to optimize cellular anticancer immunotherapy. We have recently developed a robust and simple skin test to evaluate the capacity of tumor-specific T cells to migrate, recognize their targets and exert effector functions. This bioassay detects T cells with an elevated antineoplastic potential and hence rapidly identifies patients responding to immunotherapy.

Keywords: DC-based vaccination; biomarker; delayed-type hypersensitivity; immunomonitoring; melanoma; multifunctional T cells; skin-infiltrating lymphocytes.