From neurogenetic studies in the fly brain to a concept in circadian biology

J Neurogenet. Sep-Dec 2014;28(3-4):329-47. doi: 10.3109/01677063.2014.905556. Epub 2014 May 7.


This paper is dedicated to Karl-Friedrich Fischbach, who has always shared with me the interest in the function of the fly brain, especially that of its optic lobes. He has accompanied me during my first steps in scientific research. The paper tells the story how our first common attempts to localize the circadian clock in the fly brain finally helped in phrasing the two-oscillator principle of circadian clocks that seems to be valid far beyond the fly circadian system. I hope that Karl-Friedrich will take this story as praise for his generosity in supporting younger scientists outside his own lab, even without the reward of a common paper.

Keywords: Drosophila melanogaster; circadian clock; dual-oscillator model; photoperiod; pigment-dispersing factor.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / metabolism*
  • Circadian Rhythm / physiology*
  • Drosophila Proteins / metabolism
  • Drosophila melanogaster / metabolism
  • Neurons / metabolism*


  • Drosophila Proteins