Changes of lipid and fatty acid absorption induced by high dose of citric acid ester and lecithin emulsifiers

Int J Food Sci Nutr. 2014 Sep;65(6):728-32. doi: 10.3109/09637486.2014.898261. Epub 2014 Mar 24.

Abstract

Aims: To describe the effect of two food emulsifiers, lecithin (E322) and citric acid esters of mono-and diglycerides of fatty acids (E472c), on the intestinal absorption of lipids.

Methods: The experiment was conducted on 24 male Wistar rats randomly assigned in three groups. For two groups of six rats, 30% of the lipid intake was replaced with lecithin (L) or citric acid ester of mono and diglycerides, (E); the remaining 12 rats were the control group (C). Diet and fecal fat analysis was used to determine the apparent lipid absorption (ALA) and fatty acids.

Results: ALA was significantly lower in the group E than in the groups C and L (p < 0.001). ALA of long saturated chain fatty acids decreased while the length of the carbon chains increased, and this decrease was higher in the group E.

Conclusion: E472c emulsifier decreased the intestinal absorption of lipids.

Keywords: Citric acid ester; emulsifiers; fatty acid; intestinal absorption; lecithin ester; lipids; rat.

MeSH terms

  • Animals
  • Citric Acid / pharmacology*
  • Emulsifying Agents / pharmacology*
  • Esters / pharmacology*
  • Fatty Acids / metabolism*
  • Food Additives / pharmacology
  • Intestinal Absorption / drug effects*
  • Lecithins / pharmacology*
  • Lipid Metabolism / drug effects*
  • Male
  • Rats, Wistar

Substances

  • Emulsifying Agents
  • Esters
  • Fatty Acids
  • Food Additives
  • Lecithins
  • Citric Acid