Vitamin D deficiency in alopecia areata

Br J Dermatol. 2014 Jun;170(6):1299-304. doi: 10.1111/bjd.12980.


Background: Alopecia areata (AA) is a T cell-mediated autoimmune disease that causes inflammation around anagen-stage hair follicles. Insufficient levels of vitamin D have been implicated in a variety of autoimmune diseases. Previous reports have described the effects of vitamin D on hair follicles.

Objectives: To evaluate the status of vitamin D in patients with AA, and the relationship between vitamin D levels and disease severity.

Methods: A cross-sectional study of 86 patients with AA, 44 patients with vitiligo and 58 healthy controls was conducted. The serum vitamin D levels of the study group were determined by liquid chromatography/tandem mass spectrometry.

Results: Serum 25-hydroxyvitamin D [25(OH)D] levels in patients with AA were significantly lower than those of the patients with vitiligo and the healthy controls (P = 0·001 and P < 0·001, respectively). The prevalence of 25(OH)D deficiency was significantly higher in patients with AA (91%) compared with patients with vitiligo (71%) and healthy controls (33%) (P = 0·003 and P < 0·001, respectively). Furthermore, a significant inverse correlation was found between disease severity and serum 25(OH)D level in patients with AA (r = -0·409; P < 0·001).

Conclusions: Deficient serum 25(OH)D levels are present in patients with AA and inversely correlate with disease severity. Accordingly, screening patients with AA for vitamin D deficiencies seems to be of value for the possibility of supplementing these patients with vitamin D.

MeSH terms

  • Adult
  • Age Distribution
  • Alopecia Areata / blood
  • Alopecia Areata / etiology*
  • Chromatography, Liquid
  • Cross-Sectional Studies
  • Female
  • Humans
  • Male
  • Sex Distribution
  • Tandem Mass Spectrometry
  • Vitamin D / analogs & derivatives
  • Vitamin D / metabolism
  • Vitamin D Deficiency / complications*
  • Vitiligo / blood
  • Vitiligo / etiology


  • Vitamin D
  • 25-hydroxyvitamin D