Recurrent aphthous stomatitis

Dent Clin North Am. 2014 Apr;58(2):281-97. doi: 10.1016/j.cden.2013.12.002. Epub 2014 Jan 21.


Recurrent aphthous stomatitis (RAS) is the most common ulcerative disease affecting the oral mucosa. RAS occurs mostly in healthy individuals and has an atypical clinical presentation in immunocompromised individuals. The etiology of RAS is still unknown, but several local, systemic, immunologic, genetic, allergic, nutritional, and microbial factors, as well as immunosuppressive drugs, have been proposed as causative agents. Clinical management of RAS using topical and systemic therapies is based on severity of symptoms and the frequency, size, and number of lesions. The goals of therapy are to decrease pain and ulcer size, promote healing, and decrease the frequency of recurrence.

Keywords: Aphthous; Behçet disease; Crohn disease; Immunologic; Nutritional deficiency; Psychological stress; Systemic therapy; Topical therapy.

Publication types

  • Review

MeSH terms

  • Humans
  • Recurrence
  • Risk Factors
  • Stomatitis, Aphthous / diagnosis*
  • Stomatitis, Aphthous / drug therapy
  • Stomatitis, Aphthous / etiology
  • Wound Healing / physiology