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. 2014 Apr;20(4):596-602.
doi: 10.3201/eid2004.130753.

Underdiagnosis of foodborne hepatitis A, The Netherlands, 2008-2010(1.)

Mariska Petrignani, Linda Verhoef, Harry Vennema, Rianne van Hunen, Dominique Baas, Jim E van Steenbergen, Marion P G Koopmans

Underdiagnosis of foodborne hepatitis A, The Netherlands, 2008-2010(1.)

Mariska Petrignani et al. Emerg Infect Dis. 2014 Apr.

Abstract

Outbreaks of foodborne hepatitis A are rarely recognized as such. Detection of these infections is challenging because of the infection's long incubation period and patients' recall bias. Nevertheless, the complex food market might lead to reemergence of hepatitis A virus outside of disease-endemic areas. To assess the role of food as a source of infection, we combined routine surveillance with real-time strain sequencing in the Netherlands during 2008-2010. Virus RNA from serum of 248 (59%) of 421 reported case-patients could be sequenced. Without typing, foodborne transmission was suspected for only 4% of reported case-patients. With typing, foodborne transmission increased to being the most probable source of infection for 16%. We recommend routine implementation of an enhanced surveillance system that includes prompt forwarding and typing of hepatitis A virus RNA isolated from serum, standard use of questionnaires, data sharing, and centralized interpretation of data.

Keywords: enhanced surveillance; epidemiology; foodborne diseases; hepatitis A virus; molecular typing; public health; the Netherlands; viruses.

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References

    1. Tjon GM, Coutinho RA, van den Hoek A, Esman S, Wijkmans CJ, Hoebe CJ, et al. High and persistent excretion of hepatitis A virus in immunocompetent patients. J Med Virol. 2006;78:1398–405. 10.1002/jmv.20711 - DOI - PubMed
    1. World Health Organization. The global prevalence of hepatitis A virus infection and susceptibility: a systematic review. Geneva: the Organization; 2009.
    1. Bruisten SM, van Steenbergen JE, Pijl AS, Niesters HG, van Doornum GJ, Coutinho RA. Molecular epidemiology of hepatitis A virus in Amsterdam, the Netherlands. J Med Virol. 2001;63:88–95. 10.1002/1096-9071(20000201)63:2<88::AID-JMV1001>3.0.CO;2-G - DOI - PubMed
    1. Tjon GM, Wijkmans CJ, Coutinho RA, Koek AG, van den Hoek JA, Leenders AC, et al. Molecular epidemiology of hepatitis A in Noord-Brabant, the Netherlands. J Clin Virol. 2005;32:128–36 . 10.1016/j.jcv.2004.03.008 - DOI - PubMed
    1. van Steenbergen JE, Tjon G, van den Hoek A, Koek A, Coutinho RA, Bruisten SM. Two years' prospective collection of molecular and epidemiological data shows limited spread of hepatitis A virus outside risk groups in Amsterdam, 2000–2002. J Infect Dis. 2004;189:471–82 . 10.1086/381152 - DOI - PubMed

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