In the end, what's the problem?

Mol Cell. 2014 Mar 20;53(6):855-6. doi: 10.1016/j.molcel.2014.03.008.


In this issue, Soudet et al. show that the actual mechanistic details of the chromosomal end-replication problem, the principle linking telomere biology with human cellular senescence and cancer, match previous predictions almost to the nucleotide.

Publication types

  • Comment

MeSH terms

  • Chromosomes, Fungal*
  • DNA Replication*
  • DNA, Single-Stranded*
  • Gene Expression Regulation, Fungal*
  • Saccharomyces cerevisiae / genetics*
  • Telomere / chemistry*


  • DNA, Single-Stranded