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. 2014 Mar 20;53(6):857-8.
doi: 10.1016/j.molcel.2014.03.001.

A New Bump in the Epigenetic Landscape

Free PMC article

A New Bump in the Epigenetic Landscape

Anand S Bhagwat et al. Mol Cell. .
Free PMC article


In this issue of Molecular Cell, Cheng et al. describe an unexpected role for the histone methyltransferases MLL3 and MLL4 in the repression of tissue-specific promoters, a function that prevents precocious cell differentiation in the skeletal muscle lineage.


Figure 1
Figure 1. A role for H3K4 methylation in the epigenetic control of myogenesis
Depicted is a model of myogenesis that accommodates the findings of Lee et al 2013 and Cheng et al. 2014. The pathfrom mesodermal precursor cells to differentiated myotubes is represented as a ball rolling down a hill, with the activities of various H3K4 methyltransferases either facilitating or inhibiting transitions through effects at myogenic enhancers and promoters.

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