A new bump in the epigenetic landscape

Mol Cell. 2014 Mar 20;53(6):857-8. doi: 10.1016/j.molcel.2014.03.001.

Abstract

In this issue of Molecular Cell, Cheng et al. describe an unexpected role for the histone methyltransferases MLL3 and MLL4 in the repression of tissue-specific promoters, a function that prevents precocious cell differentiation in the skeletal muscle lineage.

Publication types

  • Comment

MeSH terms

  • Animals
  • Chromatin*
  • Gene Expression Regulation, Developmental*
  • Histones / genetics*
  • Humans
  • Muscle Development / genetics*
  • Myoblasts / metabolism*

Substances

  • Chromatin
  • Histones