Resolution of recalcitrant pyogenic granuloma with laser, corticosteroid, and timolol therapy

Dermatol Online J. 2014 Mar 17;20(3):doj_21726.


A pyogenic granuloma (PG) is a rapidly growing benign vascular tumor that can be found on the skin or subcutaneous tissue. While some pyogenic granulomas may resolve spontaneously, most have a tendency to bleed easily and require treatment. Current therapeutic modalities include topical imiquimod, cryotherapy, electrodessication, curettage, excision, laser therapy, sclerotherapy, and microembolization. We report a recalcitrant case of chronic pyogenic granuloma occurring on the scalp of a healthy young male which was unresponsive to conventional surgical and non-surgical modalities. Ultimately, aggressive laser therapy, intralesional triamcinolone acetonide injections, and topical timolol application led to complete resolution and healing.

Publication types

  • Case Reports

MeSH terms

  • Administration, Cutaneous
  • Adrenal Cortex Hormones / therapeutic use
  • Adult
  • Aminoquinolines / therapeutic use
  • Anti-Bacterial Agents / therapeutic use
  • Biopsy
  • Chemotherapy, Adjuvant
  • Combined Modality Therapy
  • Drug Therapy, Combination
  • Granuloma, Pyogenic / diagnosis
  • Granuloma, Pyogenic / drug therapy
  • Granuloma, Pyogenic / pathology
  • Granuloma, Pyogenic / surgery*
  • Humans
  • Imiquimod
  • Laser Therapy*
  • Lasers, Dye / therapeutic use*
  • Lasers, Solid-State / therapeutic use*
  • Male
  • Recurrence
  • Scalp Dermatoses / drug therapy
  • Scalp Dermatoses / therapy*
  • Timolol / therapeutic use
  • Triamcinolone Acetonide / administration & dosage
  • Triamcinolone Acetonide / therapeutic use


  • Adrenal Cortex Hormones
  • Aminoquinolines
  • Anti-Bacterial Agents
  • Timolol
  • Triamcinolone Acetonide
  • Imiquimod