Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Apr;35(4):170-7.
doi: 10.1016/ Epub 2014 Mar 20.

Single Cell Behavior in T Cell Differentiation


Single Cell Behavior in T Cell Differentiation

Jan C Rohr et al. Trends Immunol. .


Upon primary infection, naïve T cells that recognize their cognate antigen become activated, proliferate, and simultaneously differentiate into various subsets. A long-standing question in the field has been how this cellular diversification is achieved. Conceptually, diverse cellular output may either arise from every single cell or only from populations of naïve cells. Furthermore, such diversity may either be driven by cell-intrinsic heterogeneity or by external, niche-derived signals. In this review, we discuss how recently developed technologies have allowed the analysis of the mechanisms underlying T cell diversification at the single cell level. In addition, we outline the implications of this work on our understanding of the formation of immunological memory, and describe a number of unresolved key questions in this field.

Keywords: T cell differentiation; asymmetric cell division; cell-extrinsic signals; cellular heterogeneity; population asymmetry; single-cell tracking.

Similar articles

See all similar articles

Cited by 13 articles

See all "Cited by" articles

LinkOut - more resources