Processing of recombinant spider silk proteins into tailor-made materials for biomaterials applications

Curr Opin Biotechnol. 2014 Oct;29:62-9. doi: 10.1016/j.copbio.2014.02.015. Epub 2014 Mar 20.


Spider silk has extraordinary mechanical properties, is biocompatible and biodegradable, and therefore an ideal material for biomedical applications. However, a drawback for any application is the inhomogeneity of spider silk, as seen for other natural materials, as well as the low availability due to the cannibalism of most spiders. Recently, developed recombinant spider silk proteins ensure constant material properties, as well as scalable production, and further the processing into morphologies other than fibres. Biotechnology enables genetic modification, broadening the range of applications, such as implant coatings, scaffolds for tissue engineering, wound dressing devices as well as drug delivery systems.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Arthropod Proteins / biosynthesis*
  • Arthropod Proteins / genetics
  • Biocompatible Materials / metabolism*
  • Biotechnology
  • Drug Delivery Systems
  • Humans
  • Recombinant Proteins / genetics
  • Recombinant Proteins / metabolism
  • Silk / biosynthesis*
  • Spiders


  • Arthropod Proteins
  • Biocompatible Materials
  • Recombinant Proteins
  • Silk