A double-blind cross-over trial of a mucin-containing artificial saliva

Br Dent J. 1989 Feb 25;166(4):115-20. doi: 10.1038/sj.bdj.4806731.


A double-blind, five phase, cross-over clinical trial was used to compare a mucin-based artificial saliva (Saliva Orthana) with its non-mucin base and water. Thirty patients, acting as their own controls, took part. Saliva Orthana offered significantly greater relief from xerostomia compared with its base or water, and was significantly better at relieving soreness than water. In terms of overall preference, it was ranked significantly higher than either alternative.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Clinical Trials as Topic
  • Double-Blind Method
  • Female
  • Gastric Mucins / therapeutic use*
  • Humans
  • Male
  • Middle Aged
  • Mouthwashes / therapeutic use*
  • Pain Management
  • Random Allocation
  • Saliva, Artificial / therapeutic use*
  • Water
  • Xerostomia / therapy*


  • Gastric Mucins
  • Mouthwashes
  • Saliva, Artificial
  • Water