Autophagosomes, phagosomes, autolysosomes, phagolysosomes, autophagolysosomes... wait, I'm confused

Autophagy. 2014 Apr;10(4):549-51. doi: 10.4161/auto.28448. Epub 2014 Mar 17.


When an autophagosome or an amphisome fuse with a lysosome, the resulting compartment is referred to as an autolysosome. Some people writing papers on the topic of autophagy use the terms "autolysosome" and "autophagolysosome" interchangeably. We contend that these words should be used to denote 2 different compartments, and that it is worthwhile maintaining this distinction-the autophagolysosome has a particular origin in the process of xenophagy that makes it distinct from an autolysosome.

Keywords: amphisome; lysosome; phagophore; stress; xenophagy.

Publication types

  • Editorial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autophagy*
  • Humans
  • Lysosomes*
  • Phagosomes*
  • Terminology as Topic*