Abstract
All-trans retinoic acid (ATRA), a component of standard therapy for acute promyelocytic leukemia (APL), is associated with potentially serious but treatable adverse effects involving numerous organ systems, including rare skeletal muscle involvement. Only a handful of cases of ATRA-induced myositis in children have been reported, and none in the radiology literature. We present such a case in a 15-year-old boy with APL, where recognition of imaging findings played a crucial role in making the diagnosis and facilitated prompt, effective treatment.
MeSH terms
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Adolescent
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Antineoplastic Agents / adverse effects*
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Antineoplastic Agents / therapeutic use
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Contrast Media
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Dexamethasone / therapeutic use
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Diagnosis, Differential
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Gadolinium
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Glucocorticoids / therapeutic use
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Humans
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Image Enhancement / methods
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Leukemia, Promyelocytic, Acute / drug therapy*
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Magnetic Resonance Imaging / methods
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Male
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Myositis / chemically induced*
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Myositis / diagnosis*
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Myositis / drug therapy
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Thigh / pathology
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Treatment Outcome
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Tretinoin / adverse effects*
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Tretinoin / therapeutic use
Substances
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Antineoplastic Agents
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Contrast Media
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Glucocorticoids
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Tretinoin
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Dexamethasone
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Gadolinium