The relationship between monoamine oxidase B (MAOB) A644G polymorphism and Parkinson disease risk: a meta-analysis

Ann Saudi Med. Jan-Feb 2014;34(1):12-7. doi: 10.5144/0256-4947.2014.12.

Abstract

Background and objectives: Many studies were conducted to assess the relationship between Monoamine oxidase B (MAOB) A644G polymorphism and susceptibility to Parkinson disease (PD). However, the results were inconsistent and inconclusive.

Design and settings: A meta-analysis was conducted from all published studies on the associations between monoamine oxidase B (MAOB) A644G polymorphism and Parkinson disease.

Methods: In this present study, the possible relationship between MAOB A644G polymorphism and PD risk was assessed by a meta-analysis. Eligible articles were identified for the period up to March 2013. Pooled odds ratios (OR) with 95% confidence intervals (CI) were appropriately derived from fixed-effects models.

Results: Twenty case-control studies with a total of 2846 cases and 3508 controls were eligible. In a recessive model, MAOB A644G polymorphism was associated with PD risk (OR=1.32, 95% CI 1.18-1.47, P < .001). Subgroup analyses by ethnicity and gender also found significant relationships between this polymorphism and PD risk.

Conclusion: This meta-analysis suggested that MAOB A644G polymorphism may be associated with PD development.

Publication types

  • Meta-Analysis

MeSH terms

  • Asians / genetics
  • Case-Control Studies
  • Female
  • Genetic Predisposition to Disease / ethnology
  • Humans
  • Male
  • Monoamine Oxidase / genetics*
  • Odds Ratio
  • Parkinson Disease / genetics*
  • Polymorphism, Genetic*
  • Risk
  • Sex Factors
  • Whites / genetics

Substances

  • Monoamine Oxidase