NAC transcription factor gene regulatory and protein-protein interaction networks in plant stress responses and senescence

Michael K Jensen; Karen Skriver

doi:10.1002/iub.1256

NAC transcription factor gene regulatory and protein-protein interaction networks in plant stress responses and senescence

IUBMB Life. 2014 Mar;66(3):156-166. doi: 10.1002/iub.1256. Epub 2014 Mar 23.

Authors

Michael K Jensen¹, Karen Skriver¹

Affiliation

¹ Department of Biology, University of Copenhagen, Ole Maaloes Vej 5, Copenhagen, Denmark.

PMID: 24659537
DOI: 10.1002/iub.1256

Abstract

Plant-specific NAM/ATAF/CUC (NAC) transcription factors (TFs) have recently received considerable attention due to their significant roles in plant development and stress signaling. Here, we summarize progress in understanding NAC TFs in stress responses and senescence. We focus on interactions between the DNA-binding NAC domain and target genes, and between the large, mostly disordered transcription regulatory domain of NAC TFs and protein interaction partners. Recent studies have identified both up-stream regulators of NAC genes and down-stream NAC target genes, outlining regulatory networks associated with NAC-protein interactions. This connects molecular interactions and signal pathway intersections with biological functions with promising use in agriculture. © 2014 IUBMB Life, 66(3):156-166, 2014.

Keywords: NAC transcription factors; gene regulatory networks; interactomes; senescence; stress response.

Publication types

Review