Tissue plasminogen activator and inflammation: from phenotype to signaling mechanisms

Am J Clin Exp Immunol. 2014 Feb 27;3(1):30-6. eCollection 2014.


In disease conditions, inflammatory cells, such as neutrophils, T cells, and monocytes/macrophages, are recruited in response to injury cues and express panoply of proinflammatory genes through a combination of transcription factors. Tissue plasminogen activator (tPA), a member of the serine protease family, has been shown to act as cytokine to activate profound receptor-mediated signaling events. In this review, we will discuss the role of tPA in inflammation in various models, and illuminate its signaling mechanisms underlying its modulation of inflammation.

Keywords: Tissue plasminogen activator; inflammation; phenotype; signaling mechanisms; tPA.

Publication types

  • Review