The Human Placenta Project: placental structure, development, and function in real time

doi:10.1016/j.placenta.2014.02.012

. 2014 May;35(5):303-4.

doi: 10.1016/j.placenta.2014.02.012. Epub 2014 Mar 6.

The Human Placenta Project: placental structure, development, and function in real time

A E Guttmacher¹, Y T Maddox¹, C Y Spong²

Affiliations

¹ Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States.
² Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States. Electronic address: spongc@mail.nih.gov.

PMID: 24661567
PMCID: PMC3999347
DOI: 10.1016/j.placenta.2014.02.012

The Human Placenta Project: placental structure, development, and function in real time

A E Guttmacher et al. Placenta. 2014 May.

. 2014 May;35(5):303-4.

doi: 10.1016/j.placenta.2014.02.012. Epub 2014 Mar 6.

Authors

A E Guttmacher¹, Y T Maddox¹, C Y Spong²

Affiliations

¹ Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States.
² Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, United States. Electronic address: spongc@mail.nih.gov.

PMID: 24661567
PMCID: PMC3999347
DOI: 10.1016/j.placenta.2014.02.012

Abstract

Despite its crucial role in the health of both the fetus and the pregnant woman, the placenta is the least understood human organ. Since a growing body of evidence also underscores the importance of placental development in the lifelong health of both mother and offspring, this lack of knowledge about placental structure and function is particularly concerning. Given modern approaches and technologies and the ability to develop new methods, we propose a coordinated "Human Placenta Project", with the ultimate goal of understanding human placental structure, development, and function in real time.

Keywords: Human placenta; Research.

Published by Elsevier Ltd.

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References

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[1] Lacroix M, Kina E, Hivert MF. Maternal/fetal determinants of insulin resistance in women during pregnancy and in offspring over life. Curr Diab Rep. 2013;13(2):238–44. - PubMed

[2] Lacroix M, Kina E, Hivert MF. Maternal/fetal determinants of insulin resistance in women during pregnancy and in offspring over life. Curr Diab Rep. 2013;13(2):238–44. - PubMed

[3] McMaster MT, Zhou Y, Fisher SJ. Abnormal placentation and the syndrome of preeclampsia. Semin Nephrol. 2004;24(6):540–7. - PubMed

[4] McMaster MT, Zhou Y, Fisher SJ. Abnormal placentation and the syndrome of preeclampsia. Semin Nephrol. 2004;24(6):540–7. - PubMed

[5] Fisher SJ. The placental problem: linking abnormal cytotrophoblast differentiation to the maternal symptoms of preeclampsia. Reprod Biol Endocrinol. 2004;2:53. - PMC - PubMed

[6] Fisher SJ. The placental problem: linking abnormal cytotrophoblast differentiation to the maternal symptoms of preeclampsia. Reprod Biol Endocrinol. 2004;2:53. - PMC - PubMed

[7] Zhou Y, Gormley MJ, Hunkapiller NM, Kapidzic M, Stolyarov Y, Feng V, Nishida M, Drake PM, Bianco K, Wang F, McMaster MT, Fisher SJ. Reversal of gene dysregulation in cultured cytotrophoblasts reveals possible causes of preeclampsia. J Clin Invest. 2013;123(7):2862–72. - PMC - PubMed

[8] Zhou Y, Gormley MJ, Hunkapiller NM, Kapidzic M, Stolyarov Y, Feng V, Nishida M, Drake PM, Bianco K, Wang F, McMaster MT, Fisher SJ. Reversal of gene dysregulation in cultured cytotrophoblasts reveals possible causes of preeclampsia. J Clin Invest. 2013;123(7):2862–72. - PMC - PubMed

[9] Silasi M, Cohen B, Karumanchi SA, Rana S. Abnormal placentation, angiogenic factors, and the pathogenesis of preeclampsia. Obstet Gynecol Clin North Am. 2010;37(2):239–53. - PubMed

[10] Silasi M, Cohen B, Karumanchi SA, Rana S. Abnormal placentation, angiogenic factors, and the pathogenesis of preeclampsia. Obstet Gynecol Clin North Am. 2010;37(2):239–53. - PubMed

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The Human Placenta Project: placental structure, development, and function in real time

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The Human Placenta Project: placental structure, development, and function in real time

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