Clinical manifestations and outcomes of the treatment of patients with GABAB encephalitis

J Neuroimmunol. 2014 May 15;270(1-2):45-50. doi: 10.1016/j.jneuroim.2014.02.011. Epub 2014 Feb 28.


Encephalitis associated with anti-γ-aminobutyric acid-B (GABAB) receptor antibodies has been identified recently. However, only a few cases have been reported to date and its clinical manifestations and prognosis have not been investigated systematically. We identified five cases of GABAB encephalitis in Korea. Here we present the clinical features, treatment responses, and brain positron emission tomography findings of the cases. The patients had a clinical triad of memory changes, seizure, and association with small-cell lung cancer. Early diagnosis and comprehensive immune modulation may provide a good outcome.

Keywords: Autoimmune synaptic encephalitis; Encephalitis; GABA(B).

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Antineoplastic Agents / therapeutic use
  • Autoantibodies / immunology
  • Autoantigens / immunology
  • Autoimmune Diseases of the Nervous System / complications
  • Autoimmune Diseases of the Nervous System / diagnosis
  • Autoimmune Diseases of the Nervous System / immunology*
  • Carcinoma, Non-Small-Cell Lung / complications
  • Carcinoma, Non-Small-Cell Lung / drug therapy
  • Female
  • Humans
  • Limbic Encephalitis / drug therapy
  • Limbic Encephalitis / immunology*
  • Limbic Encephalitis / pathology*
  • Lung Neoplasms / complications
  • Lung Neoplasms / drug therapy
  • Male
  • Middle Aged
  • Receptors, GABA-B / immunology*
  • Treatment Outcome


  • Antineoplastic Agents
  • Autoantibodies
  • Autoantigens
  • Receptors, GABA-B