Dynamic trapping and two-dimensional transport of swimming microorganisms using a rotating magnetic microrobot

Lab Chip. 2014 Jul 7;14(13):2177-82. doi: 10.1039/c4lc00004h. Epub 2014 Mar 24.

Abstract

Manipulation of microorganisms with intrinsic motility is a challenging yet important task for many biological and biomedical applications. Currently, such a task has only been accomplished using optical tweezers, while at the risk of averse heating and photodamage of the biological samples. Here, we proposed a new micro-robotic approach for fluidic trapping and two-dimensional transportation of motile microorganisms near a solid surface in fluids. We demonstrated selective trapping and transportation of individual freely swimming multi-flagellated bacteria over a distance of 30 μm (7.5 body length of the carrier) on a surface, using the rotational flows locally induced by a rotating magnetic microparticle. Only a weak uniform magnetic field (<3 mT) was applied to actuate the microparticle. The microparticle can translate on a glass substrate by rotating at a speed of up to 100 μm s(-1), while providing a fluidic force of a few to tens of pico-Newtons.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Lab-On-A-Chip Devices*
  • Magnetic Fields*
  • Optical Tweezers*
  • Serratia / cytology*
  • Serratia / metabolism*