Oxidative stress regulation by DJ-1 in the retinal pigment epithelium

Vera L Bonilha; Mary E Rayborn; Xiaoping Yang; Chengsong Xie; Huaibin Cai

doi:10.1007/978-1-4614-3209-8_81

Oxidative stress regulation by DJ-1 in the retinal pigment epithelium

Adv Exp Med Biol. 2014:801:649-54. doi: 10.1007/978-1-4614-3209-8_81.

Authors

Vera L Bonilha¹, Mary E Rayborn, Xiaoping Yang, Chengsong Xie, Huaibin Cai

Affiliation

¹ Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine, The Cole Eye Institute, i31, 9500 Euclid Avenue, 44195, Cleveland, OH, USA, bonilhav@ccf.org.

Abstract

DJ-1 is a protein expressed in many tissues including the brain where it has been extensively studied due to its association with Parkinson's Disease (PD). DJ-1 was reported to function as an antioxidant, redox-sensitive molecular chaperone, and transcription regulator, which protected cells from oxidative stress by modifying signaling pathways that regulate cell survival. Here we discuss our progress toward characterization of the DJ-1 function in the protection of RPE to oxidative stress.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Humans
Intracellular Signaling Peptides and Proteins / metabolism*
Macular Degeneration / metabolism*
Macular Degeneration / pathology
Oncogene Proteins / metabolism*
Oxidative Stress / physiology*
Parkinson Disease / metabolism*
Protein Deglycase DJ-1
Retinal Pigment Epithelium / metabolism*
Retinal Pigment Epithelium / pathology

Substances

Intracellular Signaling Peptides and Proteins
Oncogene Proteins
PARK7 protein, human
Protein Deglycase DJ-1

Abstract

Publication types

MeSH terms

Substances

Grants and funding