Cloning of GMP-140, a granule membrane protein of platelets and endothelium: sequence similarity to proteins involved in cell adhesion and inflammation

Cell. 1989 Mar 24;56(6):1033-44. doi: 10.1016/0092-8674(89)90636-3.


GMP-140 is an integral membrane glycoprotein found in secretory granules of platelets and endothelial cells. After cellular activation, it is rapidly redistributed to the plasma membrane. The cDNA-derived primary structure of GMP-140 predicts a cysteine-rich protein with multiple domains, including a "lectin" region, an "EGF" domain, nine tandem consensus repeats related to those in complement-binding proteins, a transmembrane domain, and a short cytoplasmic tail. Some cDNAs also predict a soluble protein with a deleted transmembrane segment. The domain organization of GMP-140 is similar to that of ELAM-1, a cytokine-inducible endothelial cell receptor that binds neutrophils. This similarity suggests that GMP-140 belongs to a new family of inducible receptors with related structure and function on vascular cells.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Blotting, Northern
  • Blotting, Southern
  • Cell Adhesion*
  • Cloning, Molecular*
  • Cytoplasmic Granules / analysis*
  • Cytoplasmic Granules / ultrastructure
  • DNA / analysis
  • DNA / isolation & purification
  • Endothelium, Vascular / analysis*
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / ultrastructure
  • Homeostasis
  • Humans
  • Inflammation / metabolism
  • Inflammation / physiopathology*
  • Intracellular Membranes / analysis
  • Megakaryocytes / analysis*
  • Megakaryocytes / cytology
  • Megakaryocytes / ultrastructure
  • Membrane Proteins / analysis*
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology
  • Molecular Sequence Data
  • P-Selectin
  • Platelet Membrane Glycoproteins / analysis
  • Platelet Membrane Glycoproteins / genetics*
  • Platelet Membrane Glycoproteins / physiology
  • Protein Biosynthesis


  • Membrane Proteins
  • P-Selectin
  • Platelet Membrane Glycoproteins
  • DNA

Associated data

  • GENBANK/M25322