Short-term Insulin Requirements Following Gastric Bypass Surgery in Severely Obese Women With Type 1 Diabetes

Obes Surg. 2014 Sep;24(9):1442-6. doi: 10.1007/s11695-014-1228-8.

Abstract

Background: In severely obese type 2 diabetes patients, gastric bypass surgery (GB) reduces body mass index (BMI) and hemoglobin A1c (HbA1c) and allows reduced doses of insulin and other medications. Data regarding the effects of GB on severely obese patients with type 1 diabetes are limited.

Methods: Severely obese women with type 1 diabetes (n = 9) were studied immediately before and after GB (7.7 ± 5.8 weeks, mean ± SD).

Results: On average, GB reduced mean BMI by 11% and mean HbA1c by 0.9% (from 8.0 to 7.1%), with a parallel 38% decrease in basal insulin requirements (expressed per kilogram of body weight).

Conclusion: GB rapidly decreased BMI, HbA1c, and insulin requirements in severely obese women with type 1 diabetes. However, physiologic insulin replacement remains necessary in patients with type 1 diabetes.

MeSH terms

  • Adolescent
  • Adult
  • Blood Glucose
  • Body Mass Index
  • Cohort Studies
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / complications
  • Diabetes Mellitus, Type 1 / drug therapy*
  • Female
  • Gastric Bypass*
  • Glycated Hemoglobin A / metabolism
  • Humans
  • Hypoglycemic Agents / therapeutic use*
  • Insulin / therapeutic use*
  • Middle Aged
  • Obesity, Morbid / blood
  • Obesity, Morbid / complications
  • Obesity, Morbid / surgery*
  • Young Adult

Substances

  • Blood Glucose
  • Glycated Hemoglobin A
  • Hypoglycemic Agents
  • Insulin