Utilization of rapid infusion system with cold saline in the induction of therapeutic hypothermia

J Int Med Res. 2014 Jun;42(3):744-9. doi: 10.1177/0300060514525760. Epub 2014 Mar 26.


Objective: To examine the cooling effectiveness of a rapid infusion system (RIS) during induction of therapeutic hypothermia.

Methods: This laboratory study simulated the effect of three fluid delivery methods: rapid dripping without any other equipment (control); RIS; pressure bag. Cold energy loss (℃ × min) was calculated as: (temperature of the proximal thermoprobe--temperature of the distal thermoprobe) × (total infusion time).

Results: Infusion time was significantly shorter and cold energy loss significantly lower in the RIS group than in the two other groups.

Conclusions: RIS preserves the cold energy of fluid more effectively than pressure bag or control. RIS allows for rapid infusion at a constant pressure and can be easily applied in an emergency setting.

Keywords: Induced hypothermia; cold saline; rapid infusion system.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cardiopulmonary Resuscitation / instrumentation
  • Cardiopulmonary Resuscitation / methods*
  • Cold Temperature
  • Coma / physiopathology
  • Coma / therapy*
  • Humans
  • Hypothermia, Induced / instrumentation
  • Hypothermia, Induced / methods*
  • Ice
  • Infusions, Intravenous
  • Intensive Care Units
  • Patient Simulation
  • Sodium Chloride / administration & dosage


  • Ice
  • Sodium Chloride