Abstract
Cloning and sequencing of the complementary DNA for platelet-derived endothelial cell growth factor indicates that it is a novel factor distinct from previously characterized proteins. The factor, a protein with a relative molecular mass of about 45,000, stimulates endothelial cell growth and chemotaxis in vitro and angiogenesis in vivo.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Blotting, Northern
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Blotting, Southern
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Chemotaxis
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Chick Embryo
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Cloning, Molecular
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DNA
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Mice
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Mice, Nude
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Molecular Sequence Data
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Neovascularization, Pathologic*
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Platelet-Derived Growth Factor / physiology*
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Tumor Cells, Cultured
Substances
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Platelet-Derived Growth Factor
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DNA