Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor

Nature. 1989 Apr 13;338(6216):557-62. doi: 10.1038/338557a0.


Cloning and sequencing of the complementary DNA for platelet-derived endothelial cell growth factor indicates that it is a novel factor distinct from previously characterized proteins. The factor, a protein with a relative molecular mass of about 45,000, stimulates endothelial cell growth and chemotaxis in vitro and angiogenesis in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Blotting, Northern
  • Blotting, Southern
  • Chemotaxis
  • Chick Embryo
  • Cloning, Molecular
  • DNA
  • Mice
  • Mice, Nude
  • Molecular Sequence Data
  • Neovascularization, Pathologic*
  • Platelet-Derived Growth Factor / physiology*
  • Tumor Cells, Cultured


  • Platelet-Derived Growth Factor
  • DNA