Childhood neurological morbidity and its association with gestational age, intrauterine growth retardation and perinatal stress

Paediatr Perinat Epidemiol. 1988 Jul;2(3):229-38. doi: 10.1111/j.1365-3016.1988.tb00213.x.


Data from 7-year-old children (n = 5363) enrolled prenatally during the 1960s in the Boston sector of the National Collaborative Perinatal Project (NCPP) have been used to study the associations of abnormal neurological findings at 7 years of age with gestational age, intrauterine growth-retardation (IUGR) and hypoxia-related perinatal stress. Among infants without perinatal stress, pre-term infants were at higher risk of abnormal neurological findings at 7 years than were term and post-term infants. IUGR infants, in the absence of stress, were not at any increased risk relative to non-IUGR infants. The odds ratio associated with perinatal stress increased with gestational age and was greater in the IUGR than in the non-IUGR infants.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Child
  • Child, Preschool
  • Cohort Studies
  • Developmental Disabilities / etiology*
  • Female
  • Fetal Growth Retardation*
  • Fetal Hypoxia*
  • Gestational Age*
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Multicenter Studies as Topic
  • Pregnancy
  • Prospective Studies