Population screening for colorectal cancer means getting FIT: the past, present, and future of colorectal cancer screening using the fecal immunochemical test for hemoglobin (FIT)

Gut Liver. 2014 Mar;8(2):117-30. doi: 10.5009/gnl.2014.8.2.117. Epub 2014 Mar 11.


Fecal immunochemical tests for hemoglobin (FIT) are changing the manner in which colorectal cancer (CRC) is screened. Although these tests are being performed worldwide, why is this test different from its predecessors? What evidence supports its adoption? How can this evidence best be used? This review addresses these questions and provides an understanding of FIT theory and practices to expedite international efforts to implement the use of FIT in CRC screening.

Keywords: Colorectal cancer; Colorectal cancer screening; Fecal immunochemical test for hemoglobin; Population screening.

Publication types

  • Review

MeSH terms

  • Colorectal Neoplasms / diagnosis*
  • Early Detection of Cancer / methods
  • Early Detection of Cancer / trends
  • Feces / chemistry*
  • Forecasting
  • Global Health
  • Hemoglobins / analysis*
  • Humans
  • Immunochemistry
  • Mass Screening / methods
  • Mass Screening / trends
  • Occult Blood
  • Sensitivity and Specificity


  • Hemoglobins