Multiple roles of Equarin during lens development

Dev Growth Differ. 2014 Apr;56(3):199-205. doi: 10.1111/dgd.12121. Epub 2014 Feb 20.


Since the days of Hans Spemann, the ocular lens has served as one of the most important developmental systems for elucidating the fundamental processes of induction and differentiation. Lens is an important source of signals that influence the eye development and a variety of genes expressed by the lens have been identified. The identification of additional molecule(s), especially secreted ones that might mediate signals, will extend our knowledge of the molecular mechanisms of eye and lens development. Here, we will introduce a soluble molecule, Equarin, and discuss its vital role in multiple aspects of lens development.

Keywords: Equarin; development; fibroblast growth factors; lens.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Avian Proteins / genetics
  • Avian Proteins / metabolism*
  • Cell Differentiation / physiology*
  • Chick Embryo
  • DNA, Complementary / genetics
  • Extracellular Matrix Proteins
  • Eye Proteins / genetics
  • Eye Proteins / metabolism*
  • Fibroblast Growth Factors / metabolism*
  • Gene Expression Regulation, Developmental / genetics
  • Gene Expression Regulation, Developmental / physiology*
  • Glycoproteins / genetics
  • Intercellular Signaling Peptides and Proteins
  • Lens, Crystalline / embryology*
  • Lens, Crystalline / metabolism
  • Models, Biological
  • Signal Transduction / genetics
  • Signal Transduction / physiology*
  • Tumor Suppressor Proteins / genetics


  • Avian Proteins
  • CCDC80 protein, human
  • DNA, Complementary
  • Extracellular Matrix Proteins
  • Eye Proteins
  • Glycoproteins
  • Intercellular Signaling Peptides and Proteins
  • Tumor Suppressor Proteins
  • Fibroblast Growth Factors