Abstract
A palladium-catalyzed cyanation of alkenyl halides using acetone cyanohydrin is described. A number of structurally diverse alkenylic nitrile containing compounds was prepared in one step under optimized conditions. The reaction proved to be efficient, chemoselective, easy to perform, and tolerant of a number of functional groups.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkenes / chemical synthesis*
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Alkenes / chemistry*
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Catalysis
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Combinatorial Chemistry Techniques
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Hydrocarbons, Brominated / chemical synthesis*
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Hydrocarbons, Brominated / chemistry
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Molecular Structure
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Nitriles / chemical synthesis*
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Nitriles / chemistry*
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Palladium / chemistry*
Substances
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Alkenes
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Hydrocarbons, Brominated
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Nitriles
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Palladium
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acetone cyanohydrin