Chemoselective palladium-catalyzed cyanation of alkenyl halides

Org Lett. 2014 Apr 18;16(8):2158-61. doi: 10.1021/ol500618w. Epub 2014 Mar 27.

Abstract

A palladium-catalyzed cyanation of alkenyl halides using acetone cyanohydrin is described. A number of structurally diverse alkenylic nitrile containing compounds was prepared in one step under optimized conditions. The reaction proved to be efficient, chemoselective, easy to perform, and tolerant of a number of functional groups.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemical synthesis*
  • Alkenes / chemistry*
  • Catalysis
  • Combinatorial Chemistry Techniques
  • Hydrocarbons, Brominated / chemical synthesis*
  • Hydrocarbons, Brominated / chemistry
  • Molecular Structure
  • Nitriles / chemical synthesis*
  • Nitriles / chemistry*
  • Palladium / chemistry*

Substances

  • Alkenes
  • Hydrocarbons, Brominated
  • Nitriles
  • Palladium
  • acetone cyanohydrin