Treatment with a combination of omalizumab and specific immunotherapy for severe anaphylaxis after a wasp sting

Int J Immunopathol Pharmacol. 2014 Jan-Mar;27(1):109-12. doi: 10.1177/039463201402700114.

Abstract

Hymenoptera venom anaphylaxis after bee or wasp sting is a common problem that affects about 1.2 percent to 3.5 percent of the general population. Venom-specific immunotherapy (VIT) is an established mode of treatment for immunoglobulin (Ig) E-mediated Hymenoptera venom allergy. However, VIT may often be associated with immediate anaphylaxis which can lead to treatment withdrawal. Several cases published in recent years suggest that omalizumab, used as add-on therapy may be able to prevent anaphylaxis during VIT. We report the case of a 30-year-old woman, suffering from mild persistent asthma, who had a history of severe anaphylactic reactions after yellow jacket sting, and after eating peanuts, contact with guinea pig hair, and i.v. administration of dexamethasone natrium phosphate. Initial specific immunotherapy had to be stopped due to severe anaphylaxis (hypotension, dyspnea, and angioedema). The immunotherapy was reintroduced accompanied by the anti-immunoglobulin (Ig) E monoclonal antibody omalizumab. Subcutaneous omalizumab 150 mg was initiated 4 weeks after the anaphylaxis incident and 1 day before the resumption of VIT. Rush treatment was uneventful, and the usual cumulative dose of 111.1 microg was successfully reached. The combination of omalizumab and VIT is a valid option of therapy for these patients and could reduce asthma and food allergy symptoms.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adult
  • Anaphylaxis / drug therapy*
  • Anaphylaxis / etiology
  • Anaphylaxis / immunology
  • Animals
  • Anti-Allergic Agents / administration & dosage
  • Anti-Allergic Agents / therapeutic use*
  • Antibodies, Anti-Idiotypic / administration & dosage
  • Antibodies, Anti-Idiotypic / therapeutic use*
  • Antibodies, Monoclonal, Humanized / administration & dosage
  • Antibodies, Monoclonal, Humanized / therapeutic use*
  • Desensitization, Immunologic / methods*
  • Female
  • Humans
  • Insect Bites and Stings / complications
  • Insect Bites and Stings / drug therapy*
  • Insect Bites and Stings / immunology
  • Omalizumab
  • Treatment Outcome
  • Wasp Venoms / immunology
  • Wasps*

Substances

  • Anti-Allergic Agents
  • Antibodies, Anti-Idiotypic
  • Antibodies, Monoclonal, Humanized
  • Wasp Venoms
  • Omalizumab