Zinc transport and diabetes risk

Nat Genet. 2014 Apr;46(4):323-4. doi: 10.1038/ng.2934.


Genome-wide association studies have previously identified variants in SLC30A8, encoding the zinc transporter ZnT8, associated with diabetes risk. A rare variant association study has now established the direction of effect, surprisingly showing that loss-of-function mutations in SLC30A8 are protective against diabetes.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cation Transport Proteins / genetics*
  • Diabetes Mellitus, Type 2 / genetics*
  • Humans
  • Mutation, Missense / genetics*
  • Zinc Transporter 8


  • Cation Transport Proteins
  • SLC30A8 protein, human
  • Zinc Transporter 8