The Geogenomic Mutational Atlas of Pathogens (GoMAP) web system

PLoS One. 2014 Mar 27;9(3):e92877. doi: 10.1371/journal.pone.0092877. eCollection 2014.


We present a new approach for pathogen surveillance we call Geogenomics. Geogenomics examines the geographic distribution of the genomes of pathogens, with a particular emphasis on those mutations that give rise to drug resistance. We engineered a new web system called Geogenomic Mutational Atlas of Pathogens (GoMAP) that enables investigation of the global distribution of individual drug resistance mutations. As a test case we examined mutations associated with HIV resistance to FDA-approved antiretroviral drugs. GoMAP-HIV makes use of existing public drug resistance and HIV protein sequence data to examine the distribution of 872 drug resistance mutations in ∼ 502,000 sequences for many countries in the world. We also implemented a broadened classification scheme for HIV drug resistance mutations. Several patterns for geographic distributions of resistance mutations were identified by visual mining using this web tool. GoMAP-HIV is an open access web application available at

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Communicable Diseases / etiology*
  • Databases, Genetic*
  • Genome, Microbial*
  • Genomics / methods*
  • Geography
  • Global Health
  • HIV Infections
  • Humans
  • Mutation*
  • Population Surveillance / methods*
  • Web Browser*