Dopamine transporter occupancy by methylphenidate and impulsivity in adult ADHD

Br J Psychiatry. 2014 Jun;204(6):486-7. doi: 10.1192/bjp.bp.113.132977. Epub 2014 Mar 27.


Impulsivity is a multidimensional construct, including impulsive decision-making and impulsive action, representing relatively independent neurocircuitries. ADHD is treated with methylphenidate, a drug that binds to dopamine transporters. This study in 24 adult male patients with ADHD shows that dopamine transporter occupancy by methylphenidate in the putamen correlates with improvements in cognitive but not in motor impulsivity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Attention Deficit Disorder with Hyperactivity / drug therapy*
  • Dopamine Plasma Membrane Transport Proteins / drug effects*
  • Dopamine Uptake Inhibitors / therapeutic use
  • Humans
  • Impulsive Behavior / drug effects*
  • Male
  • Methylphenidate / therapeutic use*
  • Treatment Outcome


  • Dopamine Plasma Membrane Transport Proteins
  • Dopamine Uptake Inhibitors
  • Methylphenidate