Human normal CD5+ B lymphocytes can be induced to differentiate to CD5- B lymphocytes with germinal center cell features

Blood. 1989 Apr;73(5):1259-63.


A significant proportion of cord blood CD5+ B cells express the activation molecules CD23, CD25, and transferrin receptor; react with the cell-cycle-associated monoclonal antibody (MoAb) Ki67; can be induced to enter the S phase of cell cycle by interleukin-2 (IL-2), IL-4, or low-molecular-weight B-cell growth factor (Imw-BCGF) and, exposed to IL-1 and IL-2, acquire the features (sIgD-, CD5-, CD10+, CD38+) of B blasts proliferating in the germinal centers of secondary follicles. These findings indicate that CD5+ B cells are preactivated and, in the proper microenvironment, may give rise to CD5- B cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Differentiation*
  • B-Lymphocytes / classification*
  • B-Lymphocytes / drug effects
  • B-Lymphocytes / physiology
  • CD5 Antigens
  • Cell Differentiation* / drug effects
  • Fetal Blood / cytology
  • Growth Substances / pharmacology
  • Humans
  • Lymphocyte Activation* / drug effects
  • Lymphoid Tissue / cytology*
  • Phenotype
  • Rabbits
  • Stem Cells / classification*
  • Stem Cells / drug effects
  • Stem Cells / physiology


  • Antigens, Differentiation
  • CD5 Antigens
  • Growth Substances