Drug delivery with PEGylated MoS2 nano-sheets for combined photothermal and chemotherapy of cancer

Abstract

MoS2 nanosheets functionalized with poly-ethylene glycol are for the first time used as a multifunctional drug delivery system with high drug loading capacities. Using doxorubicin as the model drug and taking advantages of the strong near-infrared absorbance of MoS2, combined photothermal and chemotherapy of cancer is realized in animal experiments, achieving excellent synergistic anti-tumor effect upon systemic administration.

Keywords: 2D nanostructure; MoS2 nanosheet; combination therapy; drug delivery; photothermal therapy.