Response of synovial fluid T cell clones to Yersinia enterocolitica antigens in patients with reactive Yersinia arthritis

Clin Exp Immunol. 1989 Mar;75(3):365-70.


From synovial fluids of two patients with reactive arthritis following Yersinia enterocolitica infection, T lymphocyte clones were obtained that showed proliferative responses to Y. enterocolitica. The responses required autologous T-cell-depleted peripheral blood mononuclear cells as antigen presenting cells. Three clones were studied in detail; two of them showed a marked and specific response to Yersinia antigens alone, the other one recognized both Yersinia and Salmonella typhimurium antigens. The antigen-specific proliferation of the clones could be completely blocked by monoclonal antibodies to HLA-DR. These experiments show that synovial T lymphocytes presumably involved in the in situ immune response to microbial antigens triggering reactive arthritis can be cloned directly from the site of inflammation.

MeSH terms

  • Adult
  • Antigens, Bacterial / immunology*
  • Arthritis, Infectious / immunology*
  • Clone Cells
  • Epitopes / immunology
  • Female
  • Humans
  • Knee Joint
  • Lymphocyte Activation
  • Male
  • Synovial Fluid / immunology*
  • T-Lymphocytes / immunology*
  • Yersinia Infections / immunology*
  • Yersinia enterocolitica / immunology


  • Antigens, Bacterial
  • Epitopes