Preclinical research: Make mouse studies work

Nature. 2014 Mar 27;507(7493):423-5. doi: 10.1038/507423a.
No abstract available

MeSH terms

  • Amyotrophic Lateral Sclerosis / genetics
  • Amyotrophic Lateral Sclerosis / pathology
  • Amyotrophic Lateral Sclerosis / therapy
  • Animals
  • Cause of Death
  • Clinical Trials as Topic / economics
  • Clinical Trials as Topic / standards
  • Disease Models, Animal*
  • Disease Progression
  • Dose-Response Relationship, Drug
  • Drug Evaluation, Preclinical / economics
  • Drug Evaluation, Preclinical / methods*
  • Drug Evaluation, Preclinical / standards*
  • False Positive Reactions
  • Guidelines as Topic
  • Half-Life
  • Humans
  • Mice
  • Organ Specificity
  • Reproducibility of Results
  • Research Design*
  • Superoxide Dismutase / deficiency
  • Superoxide Dismutase / genetics
  • Superoxide Dismutase / metabolism
  • Superoxide Dismutase-1
  • Survival Analysis
  • Translational Medical Research / economics
  • Translational Medical Research / methods*
  • Translational Medical Research / standards*
  • Treatment Failure

Substances

  • SOD1 protein, human
  • Sod1 protein, mouse
  • Superoxide Dismutase
  • Superoxide Dismutase-1