Oral administration of soy peptides suppresses cognitive decline by induction of neurotrophic factors in SAMP8 mice

J Agric Food Chem. 2014 Apr 23;62(16):3563-9. doi: 10.1021/jf405416s. Epub 2014 Apr 8.


SAMP8 mice have a shorter lifespan and show the dysfunction of the central nervous system. We here investigated whether soy peptides (SP) composed mainly of di- and tripeptides has the potential to prevent age-dependent cognitive impairment. SAMP8 and normal aging mice, SAMR1, were fed a diet supplemented with SP or a control diet for 26 weeks to investigate the preventive effects on the progression of cognitive decline using the Morris water maze. The SP-fed groups in SAMP8 and SAMR1 prevented the decline of cognitive ability compared to their controls. Increased expression of neurotrophic factors such as BDNF and NT-3 at mRNA and protein levels were observed in the brain of SP-fed mice, especially SAMP8. Further, the phosphorylated CREB protein level of SAMP8 was markedly up-regulated by SP feeding. These suggest that SPs have the potential for prevention of cognitive impairment via neurotrophic effects.

MeSH terms

  • Administration, Oral
  • Aging / drug effects*
  • Aging / metabolism
  • Aging / psychology
  • Animals
  • Cognition / drug effects*
  • Cyclic AMP Response Element-Binding Protein / genetics
  • Cyclic AMP Response Element-Binding Protein / metabolism
  • Disease Models, Animal
  • Humans
  • Male
  • Mice
  • Nerve Growth Factors / genetics*
  • Nerve Growth Factors / metabolism
  • Peptides / administration & dosage*
  • Phosphorylation / drug effects
  • Plant Extracts / administration & dosage*
  • Soybeans / chemistry*
  • Up-Regulation / drug effects


  • Cyclic AMP Response Element-Binding Protein
  • Nerve Growth Factors
  • Peptides
  • Plant Extracts