This review aims to highlight the importance of the bidirectional influence of the extracellular matrix (ECM) and immune cells in the context of type 1 diabetes mellitus (T1DM) and endocrine pancreatic islet transplantation. We introduced the main classes of molecules and proteins constituting the ECM as well as cells and cytokines of the immune system with the aim to further examine their roles in T1DM and islet transplantation. Integrins expressed by immune cells and their functions are detailed. Finally, this article reviews the roles of the ECM and the immune system in islet transplantation as well as ECM-related cytokines and their influence on the ECM and immune cells.
Keywords: Diabète type 1; Extracellular matrix; Immune system; Integrins; Intégrines; Islet transplantation; Matrice extracellulaire; Système immunitaire; Transplantation d’îlots pancréatiques endocriniens; Type 1 diabetes.
Copyright © 2014. Published by Elsevier SAS.