Ewing sarcoma

Semin Diagn Pathol. 2014 Jan;31(1):39-47. doi: 10.1053/j.semdp.2014.01.002. Epub 2014 Jan 5.


Classification of small round cell tumors of bone is often challenging due to overlapping clinicopathologic features. The purpose of this article is to review the clinical, radiological, histologic, and molecular features of Ewing sarcoma and to provide a discussion of the differential diagnosis of small round cell tumors of bone.

Keywords: Ewing family of tumors; Ewing sarcoma; Ewing-like sarcoma; Primitive neuroectodermal tumor; Small round cell sarcoma.

Publication types

  • Review

MeSH terms

  • Bone Neoplasms / classification
  • Bone Neoplasms / diagnosis
  • Bone Neoplasms / genetics*
  • Bone Neoplasms / pathology*
  • Diagnosis, Differential
  • Humans
  • Neuroectodermal Tumors, Primitive / diagnosis
  • Neuroectodermal Tumors, Primitive / genetics
  • Neuroectodermal Tumors, Primitive / pathology
  • Pathology, Molecular / methods
  • Prognosis
  • Sarcoma, Ewing / classification
  • Sarcoma, Ewing / diagnosis
  • Sarcoma, Ewing / genetics*
  • Sarcoma, Ewing / pathology*