GPCR signaling along the endocytic pathway

Curr Opin Cell Biol. 2014 Apr:27:109-16. doi: 10.1016/ Epub 2013 Dec 28.


Many G protein-coupled receptors (GPCRs) internalize after agonist-induced activation. While endocytosis has long been associated with homeostatic attenuation of cellular responsiveness, accumulating evidence from study of a wide range of eukaryotes reveals that the endocytic pathway also contributes to generating receptor-initiated signals themselves. Here we review recent progress in this area, discussing primarily but not exclusively GPCR signaling in mammalian cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Endocytosis*
  • Endosomes / metabolism
  • Humans
  • Intracellular Membranes / metabolism
  • Receptors, G-Protein-Coupled / metabolism*
  • Signal Transduction*


  • Receptors, G-Protein-Coupled