The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity

doi:10.1038/nsmb.2799

. 2014 Apr;21(4):423-5.

doi: 10.1038/nsmb.2799. Epub 2014 Mar 30.

The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity

Xinyi Lu¹, Friedrich Sachs², LeeAnn Ramsay³, Pierre-Étienne Jacques⁴, Jonathan Göke¹, Guillaume Bourque⁵, Huck-Hui Ng⁶

Affiliations

¹ Gene Regulation Laboratory, Genome Institute of Singapore, Singapore.
² 1] Gene Regulation Laboratory, Genome Institute of Singapore, Singapore. [2] Department of Biochemistry, National University of Singapore, Singapore.
³ Department of Human Genetics, McGill University, Montréal, Québec, Canada.
⁴ 1] Gene Regulation Laboratory, Genome Institute of Singapore, Singapore. [2] Département de Biologie, Université de Sherbrooke, Sherbrooke, Québec, Canada.
⁵ 1] Department of Human Genetics, McGill University, Montréal, Québec, Canada. [2] Génome Québec Innovation Center, McGill University, Montréal, Québec, Canada.
⁶ 1] Gene Regulation Laboratory, Genome Institute of Singapore, Singapore. [2] Department of Biochemistry, National University of Singapore, Singapore. [3] Department of Biological Sciences, National University of Singapore, Singapore. [4] School of Biological Sciences, Nanyang Technological University, Singapore.

PMID: 24681886
DOI: 10.1038/nsmb.2799

The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity

Xinyi Lu et al. Nat Struct Mol Biol. 2014 Apr.

. 2014 Apr;21(4):423-5.

doi: 10.1038/nsmb.2799. Epub 2014 Mar 30.

Authors

Xinyi Lu¹, Friedrich Sachs², LeeAnn Ramsay³, Pierre-Étienne Jacques⁴, Jonathan Göke¹, Guillaume Bourque⁵, Huck-Hui Ng⁶

Affiliations

¹ Gene Regulation Laboratory, Genome Institute of Singapore, Singapore.
² 1] Gene Regulation Laboratory, Genome Institute of Singapore, Singapore. [2] Department of Biochemistry, National University of Singapore, Singapore.
³ Department of Human Genetics, McGill University, Montréal, Québec, Canada.
⁴ 1] Gene Regulation Laboratory, Genome Institute of Singapore, Singapore. [2] Département de Biologie, Université de Sherbrooke, Sherbrooke, Québec, Canada.
⁵ 1] Department of Human Genetics, McGill University, Montréal, Québec, Canada. [2] Génome Québec Innovation Center, McGill University, Montréal, Québec, Canada.
⁶ 1] Gene Regulation Laboratory, Genome Institute of Singapore, Singapore. [2] Department of Biochemistry, National University of Singapore, Singapore. [3] Department of Biological Sciences, National University of Singapore, Singapore. [4] School of Biological Sciences, Nanyang Technological University, Singapore.

PMID: 24681886
DOI: 10.1038/nsmb.2799

Abstract

Human endogenous retrovirus subfamily H (HERVH) is a class of transposable elements expressed preferentially in human embryonic stem cells (hESCs). Here, we report that the long terminal repeats of HERVH function as enhancers and that HERVH is a nuclear long noncoding RNA required to maintain hESC identity. Furthermore, HERVH is associated with OCT4, coactivators and Mediator subunits. Together, these results uncover a new role of species-specific transposable elements in hESCs.

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References

1. PLoS Genet. 2013 Apr;9(4):e1003470 - PubMed
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1. Nat Rev Genet. 2008 May;9(5):397-405 - PubMed
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[1] PLoS Genet. 2013 Apr;9(4):e1003470 - PubMed

[2] PLoS Genet. 2013 Apr;9(4):e1003470 - PubMed

[3] Genome Biol. 2012 Nov 26;13(11):R107 - PubMed

[4] Genome Biol. 2012 Nov 26;13(11):R107 - PubMed

[5] PLoS Genet. 2013 May;9(5):e1003504 - PubMed

[6] PLoS Genet. 2013 May;9(5):e1003504 - PubMed

[7] Nat Rev Genet. 2008 May;9(5):397-405 - PubMed

[8] Nat Rev Genet. 2008 May;9(5):397-405 - PubMed

[9] Nat Rev Genet. 2011 May;12(5):300 - PubMed

[10] Nat Rev Genet. 2011 May;12(5):300 - PubMed

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The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity

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The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity

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