Ethnic/racial discrimination has persistent negative implications for both physical and mental health. The current study employs a risk and resilience framework to explore the joint effects of ethnic/racial discrimination and sleep disturbance on psychosocial outcomes among adolescents. In a sample of 146 minority and White adolescents (70% female), changes in depressive symptoms, anxiety, and self-esteem over 3 years are explored using growth curve models. Regardless of ethnic background, adolescents reporting high levels of ethnic/racial discrimination and poor sleep also reported a corresponding increase in depressive symptoms and lower levels of self-esteem over time. Adolescents reporting all other combinations of sleep quality and ethnic/racial discrimination reported more positive adjustment over time. The joint effects of sleep and ethnic/racial discrimination on adolescent psychosocial development are discussed.