Cerebrospinal fluid (CSF) investigations in migraine

Cephalalgia. 1989 Mar;9(1):53-7. doi: 10.1046/j.1468-2982.1989.0901053.x.


A normal cell count as well as normal CSF pressure levels were found in both classic and common migraine patients during and between attacks. Total protein content was significantly lower in the migraine patients than in the controls, but no changes were found in the CSF protein fractions. The CSF 5-hydroxyindoleacetic acid level of the migraine patients proved to be higher than in the controls, whereas the homovanillic acid concentration was within the control limits.

MeSH terms

  • Adult
  • Cerebrospinal Fluid Pressure
  • Cerebrospinal Fluid Proteins / analysis
  • Female
  • Homovanillic Acid / cerebrospinal fluid
  • Humans
  • Hydroxyindoleacetic Acid / cerebrospinal fluid
  • Male
  • Migraine Disorders / cerebrospinal fluid*
  • Migraine Disorders / physiopathology


  • Cerebrospinal Fluid Proteins
  • Hydroxyindoleacetic Acid
  • Homovanillic Acid