Three new vibralactone-related compounds from cultures of Basidiomycete Boreostereum vibrans

J Asian Nat Prod Res. 2014;16(5):447-52. doi: 10.1080/10286020.2014.901312. Epub 2014 Apr 1.

Abstract

Three new compounds, named as vibralactones K-M (1-3), together with vibralactone (4) have been isolated from cultures of the Basidiomycete Boreostereum vibrans. Their structures were determined on the basis of spectroscopic evidences (1D and 2D NMR, HRMS, UV, and IR data), chemical methods and literature data. None of the compounds was cytotoxic against five human cancer cell lines and showed inhibitory activity on the pancreatic lipase.

Keywords: Basidiomycete; Boreostereum vibrans; vibralactone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Basidiomycota / chemistry*
  • Humans
  • Lactones / chemistry
  • Lactones / isolation & purification*
  • Lipase / antagonists & inhibitors*
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Pancreas / enzymology

Substances

  • Lactones
  • vibralactone
  • vibralactone K
  • vibralactone L
  • vibralactone M
  • Lipase